Drug interactions
Aspirin rectal + Triamterene
Severity: Moderate
Aspirin rectal and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin acts like oral aspirin on renal prostaglandins. With triamterene, high doses may reduce diuretic effect and raise the risk of hyperkalemia and renal impairment.
What this interaction means in plain words
Aspirin rectal and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal perfusion and potassium excretion, adding to triamterene's potassium retention.
What to do
Monitor serum potassium and renal function if regular or high-dose aspirin is needed. Keep the aspirin dose as low as practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Aspirin rectal with Triamterene?
MediHelp rates the interaction as moderate. Aspirin rectal and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin acts like oral aspirin on renal prostaglandins. With triamterene, high doses may reduce diuretic effect and raise the risk of hyperkalemia and renal impairment.
How serious is the interaction between Aspirin rectal and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function if regular or high-dose aspirin is needed. Keep the aspirin dose as low as practical.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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