Drug interactions
Aspirin rectal + Valsartan
Severity: Moderate
Aspirin rectal and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Occasional low-dose aspirin has little effect on valsartan. Regular high-dose aspirin may reduce its antihypertensive effect and impair renal function. Rectal use does not avoid systemic prostaglandin inhibition.
What this interaction means in plain words
Aspirin rectal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
High-dose aspirin inhibits renal prostaglandin synthesis, reducing renal perfusion and opposing ARB effect.
What to do
Low-dose aspirin needs no change. With regular analgesic doses, monitor blood pressure, creatinine and potassium and ensure hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Aspirin rectal with Valsartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Occasional low-dose aspirin has little effect on valsartan. Regular high-dose aspirin may reduce its antihypertensive effect and impair renal function. Rectal use does not avoid systemic prostaglandin inhibition.
How serious is the interaction between Aspirin rectal and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Low-dose aspirin needs no change. With regular analgesic doses, monitor blood pressure, creatinine and potassium and ensure hydration.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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