Drug interactions
Atenolol + Drospirenone
Severity: Minor
Atenolol and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Beta-blockers can also modestly raise potassium by impairing cellular uptake, so hyperkalemia is possible, mainly with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Atenolol and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium elevation: aldosterone antagonism by drospirenone and reduced beta-2-mediated cellular potassium uptake with beta-blockade.
What to do
Check serum potassium in the first cycle in patients at risk, such as those with renal impairment or on other potassium-raising drugs. Routine monitoring is otherwise not required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Atenolol with Drospirenone?
MediHelp rates the interaction as minor. Atenolol and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Beta-blockers can also modestly raise potassium by impairing cellular uptake, so hyperkalemia is possible, mainly with renal impairment or other potassium-raising drugs.
How serious is the interaction between Atenolol and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle in patients at risk, such as those with renal impairment or on other potassium-raising drugs. Routine monitoring is otherwise not required.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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