Drug interactions
Atenolol + Fingolimod
Severity: Major
Atenolol and Fingolimod: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes transient heart rate slowing and AV conduction delay after the first dose, and atenolol adds to these effects. Symptomatic bradycardia or AV block is more likely.
What this interaction means in plain words
Atenolol and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol belongs to Cardiovascular; Fingolimod belongs to Central Nervous System.
Why it happens
Additive negative chronotropic and dromotropic effects via S1P receptor modulation and beta-blockade.
What to do
Obtain an ECG before starting and observe heart rate and blood pressure for at least 6 hours after the first dose, or consider an alternative to the beta-blocker with the prescriber.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Atenolol with Fingolimod?
MediHelp rates the interaction as major. Atenolol and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod causes transient heart rate slowing and AV conduction delay after the first dose, and atenolol adds to these effects. Symptomatic bradycardia or AV block is more likely.
How serious is the interaction between Atenolol and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting and observe heart rate and blood pressure for at least 6 hours after the first dose, or consider an alternative to the beta-blocker with the prescriber.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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