Drug interactions
Atenolol + Mavacamten
Severity: Moderate
Atenolol and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility and beta-blockers have negative inotropic effects. Together they can cause excessive reduction in systolic function and heart failure, although beta-blockers are often used in obstructive hypertrophic cardiomyopathy.
What this interaction means in plain words
Atenolol and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects.
What to do
Monitor LVEF and symptoms with echocardiography per mavacamten labeling. Interrupt mavacamten if LVEF falls or heart failure develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol and Mavacamten, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Atenolol with Mavacamten?
MediHelp rates the interaction as moderate. Atenolol and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten reduces cardiac contractility and beta-blockers have negative inotropic effects. Together they can cause excessive reduction in systolic function and heart failure, although beta-blockers are often used in obstructive hypertrophic cardiomyopathy.
How serious is the interaction between Atenolol and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and symptoms with echocardiography per mavacamten labeling. Interrupt mavacamten if LVEF falls or heart failure develops.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
