Drug interactions
Atenolol + Naproxen
Severity: Moderate
Atenolol and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can blunt the blood pressure lowering effect of atenolol, particularly with regular use over more than a week. Fluid retention and reduced renal prostaglandins contribute to this loss of control.
What this interaction means in plain words
Atenolol and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention that opposes beta-blocker antihypertensive action.
What to do
Monitor blood pressure when naproxen is started, changed or stopped, and adjust antihypertensive therapy if needed. Limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Naproxen?
MediHelp rates the interaction as moderate. Atenolol and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can blunt the blood pressure lowering effect of atenolol, particularly with regular use over more than a week. Fluid retention and reduced renal prostaglandins contribute to this loss of control.
How serious is the interaction between Atenolol and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when naproxen is started, changed or stopped, and adjust antihypertensive therapy if needed. Limit NSAID dose and duration.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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