Drug interactions
Atenolol + Nebivolol
Severity: Major
Atenolol and Nebivolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-1 selective blockers, so combining them duplicates therapy. The result can be excessive bradycardia, hypotension and AV block without added benefit.
What this interaction means in plain words
Atenolol and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic beta-1 adrenergic blockade.
What to do
Avoid the combination and use one beta blocker. Monitor heart rate and blood pressure if both are given briefly during a switch.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Nebivolol
Frequently asked questions
Can I take Atenolol with Nebivolol?
MediHelp rates the interaction as major. Atenolol and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are beta-1 selective blockers, so combining them duplicates therapy. The result can be excessive bradycardia, hypotension and AV block without added benefit.
How serious is the interaction between Atenolol and Nebivolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use one beta blocker. Monitor heart rate and blood pressure if both are given briefly during a switch.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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