Drug interactions
Amiodarone + Nebivolol
Severity: Major
Amiodarone and Nebivolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone and beta-blockers have additive effects on the sinus and AV nodes and may cause severe bradycardia or heart block. Amiodarone also inhibits CYP2D6 and may raise nebivolol levels.
What this interaction means in plain words
Amiodarone and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects, plus CYP2D6 inhibition by amiodarone.
What to do
Monitor ECG and heart rate, especially at initiation. Reduce the nebivolol dose or avoid the combination in sinus node dysfunction or AV block.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
- Bisoprolol + Nebivolol Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Nebivolol?
MediHelp rates the interaction as major. Amiodarone and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone and beta-blockers have additive effects on the sinus and AV nodes and may cause severe bradycardia or heart block. Amiodarone also inhibits CYP2D6 and may raise nebivolol levels.
How serious is the interaction between Amiodarone and Nebivolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, especially at initiation. Reduce the nebivolol dose or avoid the combination in sinus node dysfunction or AV block.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Atenolol-chlorthalidone. The full list is on the Nebivolol page.
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