Drug interactions
Atenolol + Sacubitril-valsartan
Severity: Minor
Atenolol and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atenolol and sacubitril/valsartan are both used in heart failure and hypertension and together can lower blood pressure and heart rate more than either alone. This combination is commonly used, and the effect is usually manageable with monitoring.
What this interaction means in plain words
Atenolol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through beta-blockade and angiotensin receptor and neprilysin inhibition.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug. Adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Atenolol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atenolol and sacubitril/valsartan are both used in heart failure and hypertension and together can lower blood pressure and heart rate more than either alone. This combination is commonly used, and the effect is usually manageable with monitoring.
How serious is the interaction between Atenolol and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug. Adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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