Drug interactions
Atenolol + Timolol
Severity: Moderate
Atenolol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining oral atenolol with timolol, which is a nonselective beta-blocker, duplicates therapy and increases the risk of bradycardia, hypotension and AV block. Systemic timolol exposure also occurs from eye drops and may add to the effect.
What this interaction means in plain words
Atenolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic receptor blockade.
What to do
Avoid duplicate oral beta-blockade. If timolol eye drops are used with atenolol, monitor heart rate and blood pressure and consider a non-beta-blocker glaucoma agent in patients with bradycardia or asthma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Atenolol with Timolol?
MediHelp rates the interaction as moderate. Atenolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining oral atenolol with timolol, which is a nonselective beta-blocker, duplicates therapy and increases the risk of bradycardia, hypotension and AV block. Systemic timolol exposure also occurs from eye drops and may add to the effect.
How serious is the interaction between Atenolol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate oral beta-blockade. If timolol eye drops are used with atenolol, monitor heart rate and blood pressure and consider a non-beta-blocker glaucoma agent in patients with bradycardia or asthma.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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