Drug interactions
Atenolol-chlorthalidone + Chlorpropamide
Severity: Moderate
Atenolol-chlorthalidone and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise blood glucose and so reduce the effectiveness of chlorpropamide. Both drugs can also contribute to hyponatremia, and atenolol may mask hypoglycemia symptoms. Glycemic control may therefore need adjustment.
What this interaction means in plain words
Atenolol-chlorthalidone and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
Thiazide-induced impaired insulin secretion and insulin resistance oppose sulfonylurea action, with additive effects on sodium.
What to do
Monitor blood glucose and serum sodium after starting chlorthalidone, and adjust the antidiabetic regimen as needed. Warn patients that beta-blockade may mask hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Atenolol-chlorthalidone with Chlorpropamide?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone can raise blood glucose and so reduce the effectiveness of chlorpropamide. Both drugs can also contribute to hyponatremia, and atenolol may mask hypoglycemia symptoms. Glycemic control may therefore need adjustment.
How serious is the interaction between Atenolol-chlorthalidone and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting chlorthalidone, and adjust the antidiabetic regimen as needed. Warn patients that beta-blockade may mask hypoglycemia symptoms.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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