Drug interactions
Atenolol-chlorthalidone + Cocaine
Severity: Moderate
Atenolol-chlorthalidone and Cocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers may leave alpha-adrenergic effects of cocaine unopposed, which can worsen coronary vasoconstriction and hypertension. With topical cocaine the systemic exposure is small, but the risk is greater with intranasal or illicit use.
What this interaction means in plain words
Atenolol-chlorthalidone and Cocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Cocaine belongs to Central Nervous System.
Why it happens
Beta-blockade leaves cocaine-induced alpha-mediated vasoconstriction unopposed.
What to do
Avoid beta-blockers in patients with acute cocaine intoxication. For topical medical use, use the lowest effective dose and monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Cocaine?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Cocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers may leave alpha-adrenergic effects of cocaine unopposed, which can worsen coronary vasoconstriction and hypertension. With topical cocaine the systemic exposure is small, but the risk is greater with intranasal or illicit use.
How serious is the interaction between Atenolol-chlorthalidone and Cocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid beta-blockers in patients with acute cocaine intoxication. For topical medical use, use the lowest effective dose and monitor blood pressure and heart rate.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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