Drug interactions
Cocaine + Procarbazine
Severity: Contraindicated
Cocaine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
What this interaction means in plain words
Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition increases monoamine stores while cocaine blocks reuptake, producing additive sympathomimetic and serotonergic effects.
What to do
Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
- Clomipramine + Cocaine Major
Frequently asked questions
Can I take Cocaine with Procarbazine?
MediHelp rates the interaction as contraindicated. Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
How serious is the interaction between Cocaine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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