Drug interactions
Atenolol-chlorthalidone + Colestipol
Severity: Moderate
Atenolol-chlorthalidone and Colestipol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that binds to acidic drugs in the gut and can reduce absorption of thiazide-type diuretics. This may weaken the diuretic and antihypertensive effect of chlorthalidone.
What this interaction means in plain words
Atenolol-chlorthalidone and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Colestipol belongs to Cardiovascular.
Why it happens
Binding of chlorthalidone in the gastrointestinal tract, reducing its absorption.
What to do
Give atenolol-chlorthalidone at least 1 hour before or 4 hours after colestipol. Monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
- Chenodeoxycholic acid + Colestipol Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Colestipol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that binds to acidic drugs in the gut and can reduce absorption of thiazide-type diuretics. This may weaken the diuretic and antihypertensive effect of chlorthalidone.
How serious is the interaction between Atenolol-chlorthalidone and Colestipol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atenolol-chlorthalidone at least 1 hour before or 4 hours after colestipol. Monitor blood pressure.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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