Drug interactions
Candesartan-hydrochlorothiazide + Colestipol
Severity: Moderate
Candesartan-hydrochlorothiazide and Colestipol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol binds hydrochlorothiazide in the gut and reduces its absorption, which can blunt the diuretic and antihypertensive effect. The effect is dose-timing dependent and can be avoided by separating administration.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Colestipol belongs to Cardiovascular.
Why it happens
Bile acid sequestrant binds hydrochlorothiazide in the gastrointestinal tract, reducing absorption.
What to do
Give hydrochlorothiazide at least 4 hours before or after colestipol, and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
- Chenodeoxycholic acid + Colestipol Moderate
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Colestipol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol binds hydrochlorothiazide in the gut and reduces its absorption, which can blunt the diuretic and antihypertensive effect. The effect is dose-timing dependent and can be avoided by separating administration.
How serious is the interaction between Candesartan-hydrochlorothiazide and Colestipol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give hydrochlorothiazide at least 4 hours before or after colestipol, and monitor blood pressure.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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