Drug interactions
Atenolol-chlorthalidone + Deflazacort
Severity: Moderate
Atenolol-chlorthalidone and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a corticosteroid with some mineralocorticoid activity, and chlorthalidone wastes potassium. Together they increase the risk of hypokalemia, which may provoke arrhythmias or muscle weakness.
What this interaction means in plain words
Atenolol-chlorthalidone and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Additive renal potassium loss from thiazide-like diuresis and corticosteroid effects.
What to do
Check serum potassium and magnesium at baseline and periodically. Supplement potassium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Deflazacort?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a corticosteroid with some mineralocorticoid activity, and chlorthalidone wastes potassium. Together they increase the risk of hypokalemia, which may provoke arrhythmias or muscle weakness.
How serious is the interaction between Atenolol-chlorthalidone and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically. Supplement potassium if levels fall.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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