Drug interactions
Atenolol-chlorthalidone + Drospirenone
Severity: Moderate
Atenolol-chlorthalidone and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, while chlorthalidone lowers it, so the net effect is unpredictable. Hyperkalemia is more likely with renal impairment or other potassium-raising drugs, and atenolol may add a small potassium-raising effect.
What this interaction means in plain words
Atenolol-chlorthalidone and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Drospirenone's antimineralocorticoid action retains potassium, opposing the potassium loss caused by chlorthalidone.
What to do
Check serum potassium during the first treatment cycle and periodically afterward, particularly in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Drospirenone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Drospirenone?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, while chlorthalidone lowers it, so the net effect is unpredictable. Hyperkalemia is more likely with renal impairment or other potassium-raising drugs, and atenolol may add a small potassium-raising effect.
How serious is the interaction between Atenolol-chlorthalidone and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle and periodically afterward, particularly in patients with renal impairment.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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