Drug interactions
Atenolol-chlorthalidone + Epoprostenol
Severity: Moderate
Atenolol-chlorthalidone and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator, and diuretics and beta-blockers also lower blood pressure. Combined use can cause additive hypotension, especially at dose increases.
What this interaction means in plain words
Atenolol-chlorthalidone and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive blood pressure lowering through vasodilation, diuresis and beta-blockade.
What to do
Monitor blood pressure and heart rate during initiation and titration of epoprostenol, and adjust antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Epoprostenol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator, and diuretics and beta-blockers also lower blood pressure. Combined use can cause additive hypotension, especially at dose increases.
How serious is the interaction between Atenolol-chlorthalidone and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and titration of epoprostenol, and adjust antihypertensive doses if hypotension occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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