Drug interactions
Atenolol-chlorthalidone + Eprosartan
Severity: Moderate
Atenolol-chlorthalidone and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an angiotensin receptor blocker with a beta-blocker and a diuretic produces additive blood pressure lowering, and first-dose hypotension may occur especially with volume depletion. Eprosartan can also raise potassium and affect renal function, while chlorthalidone tends to lower potassium. Eprosartan is also harmful in pregnancy.
What this interaction means in plain words
Atenolol-chlorthalidone and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with opposing effects on potassium and RAAS blockade-related renal changes.
What to do
Monitor blood pressure, serum potassium and creatinine after starting or changing doses. Avoid in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Eprosartan?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an angiotensin receptor blocker with a beta-blocker and a diuretic produces additive blood pressure lowering, and first-dose hypotension may occur especially with volume depletion. Eprosartan can also raise potassium and affect renal function, while chlorthalidone tends to lower potassium. Eprosartan is also harmful in pregnancy.
How serious is the interaction between Atenolol-chlorthalidone and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after starting or changing doses. Avoid in pregnancy.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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