Drug interactions
Atenolol-chlorthalidone + Etrasimod
Severity: Moderate
Atenolol-chlorthalidone and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and delay AV conduction when started. With atenolol, additive bradycardia or conduction block is possible, though stable beta-blocker use showed no additive effect on heart rate.
What this interaction means in plain words
Atenolol-chlorthalidone and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Sphingosine-1-phosphate receptor modulation slows heart rate and AV conduction, adding to beta-blocker effects.
What to do
Obtain a baseline ECG before starting etrasimod and seek cardiology advice in patients on beta-blockers; monitor heart rate if beta-blockers are started afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Etrasimod?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently slow heart rate and delay AV conduction when started. With atenolol, additive bradycardia or conduction block is possible, though stable beta-blocker use showed no additive effect on heart rate.
How serious is the interaction between Atenolol-chlorthalidone and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting etrasimod and seek cardiology advice in patients on beta-blockers; monitor heart rate if beta-blockers are started afterward.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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