Drug interactions
Anagrelide + Etrasimod
Severity: Major
Anagrelide and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachycardia and palpitations. Etrasimod causes transient slowing of heart rate and AV conduction delay on initiation, and bradycardia increases the risk of torsades de pointes with QT-prolonging drugs.
What this interaction means in plain words
Anagrelide and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation with etrasimod-induced bradycardia and conduction delay.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting. Monitor ECG and heart rate, or consider an alternative agent in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anagrelide and Etrasimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
- Baricitinib + Etrasimod Major
Frequently asked questions
Can I take Anagrelide with Etrasimod?
MediHelp rates the interaction as major. Anagrelide and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anagrelide can prolong the QT interval and cause tachycardia and palpitations. Etrasimod causes transient slowing of heart rate and AV conduction delay on initiation, and bradycardia increases the risk of torsades de pointes with QT-prolonging drugs.
How serious is the interaction between Anagrelide and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting. Monitor ECG and heart rate, or consider an alternative agent in patients with other QT risk factors.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
