Drug interactions
Atenolol-chlorthalidone + Hydralazine
Severity: Minor
Atenolol-chlorthalidone and Hydralazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydralazine adds vasodilation to the blood pressure lowering of atenolol and chlorthalidone, which is a common deliberate combination. Beta-blockade reduces the reflex tachycardia caused by hydralazine, but excessive hypotension can occur.
What this interaction means in plain words
Atenolol-chlorthalidone and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol-chlorthalidone belongs to Cardiovascular; Hydralazine belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through vasodilation, beta-blockade and diuresis.
What to do
Monitor blood pressure and titrate doses gradually. Watch for orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol-chlorthalidone and Hydralazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Hydralazine?
MediHelp rates the interaction as minor. Atenolol-chlorthalidone and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydralazine adds vasodilation to the blood pressure lowering of atenolol and chlorthalidone, which is a common deliberate combination. Beta-blockade reduces the reflex tachycardia caused by hydralazine, but excessive hypotension can occur.
How serious is the interaction between Atenolol-chlorthalidone and Hydralazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate doses gradually. Watch for orthostatic symptoms.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
