Drug interactions
Atenolol-chlorthalidone + Insulin degludec
Severity: Moderate
Atenolol-chlorthalidone and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise blood glucose and so reduce the effect of insulin. Atenolol can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations and may prolong recovery from low glucose.
What this interaction means in plain words
Atenolol-chlorthalidone and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazide-induced impairment of glucose tolerance and beta-blocker suppression of hypoglycemia symptoms and glycogenolysis.
What to do
Monitor blood glucose more frequently after starting or adjusting therapy and adjust insulin as required. Educate the patient that sweating may be the only hypoglycemia warning sign.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Insulin degludec
Frequently asked questions
Can I take Atenolol-chlorthalidone with Insulin degludec?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone can raise blood glucose and so reduce the effect of insulin. Atenolol can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations and may prolong recovery from low glucose.
How serious is the interaction between Atenolol-chlorthalidone and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting or adjusting therapy and adjust insulin as required. Educate the patient that sweating may be the only hypoglycemia warning sign.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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