Drug interactions
Insulin degludec + Insulin glargine-lixisenatide
Severity: Major
Insulin degludec and Insulin glargine-lixisenatide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination product already contains basal insulin, so adding insulin degludec duplicates basal insulin therapy. The result is a high risk of hypoglycemia from overlapping basal coverage.
What this interaction means in plain words
Insulin degludec and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Therapeutic duplication with additive insulin effect.
What to do
Avoid using two basal insulins together; use one regimen and adjust doses to the patient's glycemic needs. If switching, stop the other basal insulin and monitor glucose closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Insulin glargine-lixisenatide?
MediHelp rates the interaction as major. Insulin degludec and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This combination product already contains basal insulin, so adding insulin degludec duplicates basal insulin therapy. The result is a high risk of hypoglycemia from overlapping basal coverage.
How serious is the interaction between Insulin degludec and Insulin glargine-lixisenatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two basal insulins together; use one regimen and adjust doses to the patient's glycemic needs. If switching, stop the other basal insulin and monitor glucose closely.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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