Drug interactions
Atenolol-chlorthalidone + Mavacamten
Severity: Moderate
Atenolol-chlorthalidone and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility and beta-blockers also have negative inotropic effects, so heart failure from systolic dysfunction may occur. Beta-blockers are often used with mavacamten in obstructive cardiomyopathy, but additive effects need monitoring.
What this interaction means in plain words
Atenolol-chlorthalidone and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects through cardiac myosin inhibition and beta-blockade.
What to do
Monitor left ventricular ejection fraction and symptoms per mavacamten labeling. Interrupt mavacamten if ejection fraction falls or heart failure develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Mavacamten?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten reduces cardiac contractility and beta-blockers also have negative inotropic effects, so heart failure from systolic dysfunction may occur. Beta-blockers are often used with mavacamten in obstructive cardiomyopathy, but additive effects need monitoring.
How serious is the interaction between Atenolol-chlorthalidone and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and symptoms per mavacamten labeling. Interrupt mavacamten if ejection fraction falls or heart failure develops.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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