Drug interactions
Atenolol-chlorthalidone + Repaglinide
Severity: Moderate
Atenolol-chlorthalidone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone may raise blood glucose and reduce the effect of repaglinide. Atenolol can mask adrenergic symptoms of hypoglycemia, which matters with insulin secretagogues.
What this interaction means in plain words
Atenolol-chlorthalidone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Thiazide-induced glucose intolerance opposes repaglinide, and beta-blockade masks hypoglycemia warning signs.
What to do
Monitor blood glucose after starting or changing therapy and adjust repaglinide as needed. Counsel patients that sweating may be the main hypoglycemia sign.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol-chlorthalidone and Repaglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Repaglinide?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone may raise blood glucose and reduce the effect of repaglinide. Atenolol can mask adrenergic symptoms of hypoglycemia, which matters with insulin secretagogues.
How serious is the interaction between Atenolol-chlorthalidone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing therapy and adjust repaglinide as needed. Counsel patients that sweating may be the main hypoglycemia sign.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
