Drug interactions
Cyclosporin + Repaglinide
Severity: Major
Cyclosporin and Repaglinide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine raises repaglinide exposure, increasing the risk of prolonged or severe hypoglycemia.
What this interaction means in plain words
Cyclosporin and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Repaglinide belongs to Endocrine.
Why it happens
Cyclosporine inhibits CYP3A4 and OATP1B1, reducing hepatic uptake and metabolism of repaglinide.
What to do
Keep repaglinide at a low dose, not exceeding the labeled daily maximum with cyclosporine. Monitor blood glucose more frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Cyclosporin with Repaglinide?
MediHelp rates the interaction as major. Cyclosporin and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises repaglinide exposure, increasing the risk of prolonged or severe hypoglycemia.
How serious is the interaction between Cyclosporin and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep repaglinide at a low dose, not exceeding the labeled daily maximum with cyclosporine. Monitor blood glucose more frequently.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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