Drug interactions
Atenolol-chlorthalidone + Salmeterol
Severity: Moderate
Atenolol-chlorthalidone and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atenolol is a beta-1 selective blocker that may reduce the bronchodilator benefit of salmeterol, mainly at higher doses or in patients with reactive airways. Salmeterol and chlorthalidone both lower serum potassium, which can add to hypokalemia and arrhythmia risk.
What this interaction means in plain words
Atenolol-chlorthalidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-adrenoceptors plus additive potassium lowering from beta-2 stimulation and thiazide diuresis.
What to do
Monitor respiratory symptoms and serum potassium, particularly with higher salmeterol doses. Replace potassium as needed and reassess the beta-blocker if asthma control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol-chlorthalidone and Salmeterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Salmeterol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atenolol is a beta-1 selective blocker that may reduce the bronchodilator benefit of salmeterol, mainly at higher doses or in patients with reactive airways. Salmeterol and chlorthalidone both lower serum potassium, which can add to hypokalemia and arrhythmia risk.
How serious is the interaction between Atenolol-chlorthalidone and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and serum potassium, particularly with higher salmeterol doses. Replace potassium as needed and reassess the beta-blocker if asthma control worsens.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
