Drug interactions
Atenolol-chlorthalidone + Tadalafil
Severity: Moderate
Atenolol-chlorthalidone and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has vasodilating properties and can add to the blood pressure lowering effect of atenolol and chlorthalidone. This may cause symptomatic hypotension, especially in volume-depleted patients or those on several antihypertensives.
What this interaction means in plain words
Atenolol-chlorthalidone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition combined with beta-blockade and diuretic effects.
What to do
Use the lowest tadalafil dose initially and monitor blood pressure and orthostatic symptoms. Confirm that no nitrates are being used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Tadalafil?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has vasodilating properties and can add to the blood pressure lowering effect of atenolol and chlorthalidone. This may cause symptomatic hypotension, especially in volume-depleted patients or those on several antihypertensives.
How serious is the interaction between Atenolol-chlorthalidone and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest tadalafil dose initially and monitor blood pressure and orthostatic symptoms. Confirm that no nitrates are being used.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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