Drug interactions
Atenolol-chlorthalidone + Terazosin
Severity: Moderate
Atenolol-chlorthalidone and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terazosin is an alpha-1 blocker and, when added to atenolol and chlorthalidone, produces additive blood pressure lowering. Patients may develop symptomatic hypotension, especially orthostatic hypotension and first-dose syncope. Beta-blockers can also blunt the reflex tachycardia that would normally compensate.
What this interaction means in plain words
Atenolol-chlorthalidone and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering from alpha-1 blockade combined with beta-blockade and diuresis.
What to do
Begin terazosin at the lowest dose at bedtime and titrate slowly, checking standing and sitting blood pressure. Counsel patients to rise slowly and reduce other antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Terazosin?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terazosin is an alpha-1 blocker and, when added to atenolol and chlorthalidone, produces additive blood pressure lowering. Patients may develop symptomatic hypotension, especially orthostatic hypotension and first-dose syncope. Beta-blockers can also blunt the reflex tachycardia that would normally compensate.
How serious is the interaction between Atenolol-chlorthalidone and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin terazosin at the lowest dose at bedtime and titrate slowly, checking standing and sitting blood pressure. Counsel patients to rise slowly and reduce other antihypertensive doses if hypotension occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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