Drug interactions
Atenolol-chlorthalidone + Tolmetin
Severity: Moderate
Atenolol-chlorthalidone and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin, like other NSAIDs, can reduce the blood pressure lowering effect of atenolol and chlorthalidone by promoting sodium and water retention. The combination with a diuretic also raises the risk of acute kidney injury, especially in dehydrated or elderly patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causing fluid retention and reduced renal blood flow.
What to do
Monitor blood pressure and renal function during use of tolmetin. Limit NSAID dose and duration, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Tolmetin?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin, like other NSAIDs, can reduce the blood pressure lowering effect of atenolol and chlorthalidone by promoting sodium and water retention. The combination with a diuretic also raises the risk of acute kidney injury, especially in dehydrated or elderly patients.
How serious is the interaction between Atenolol-chlorthalidone and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during use of tolmetin. Limit NSAID dose and duration, and ensure adequate hydration.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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