Drug interactions
Atenolol-chlorthalidone + Valsartan
Severity: Moderate
Atenolol-chlorthalidone and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan adds to the antihypertensive effect of atenolol and chlorthalidone, which can cause hypotension and renal function changes, especially with volume depletion. Valsartan can raise potassium and is contraindicated in pregnancy because of fetal harm.
What this interaction means in plain words
Atenolol-chlorthalidone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering, with angiotensin receptor blockade reducing aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure, serum potassium, and creatinine after initiation or dose change. Avoid in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Valsartan?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan adds to the antihypertensive effect of atenolol and chlorthalidone, which can cause hypotension and renal function changes, especially with volume depletion. Valsartan can raise potassium and is contraindicated in pregnancy because of fetal harm.
How serious is the interaction between Atenolol-chlorthalidone and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, and creatinine after initiation or dose change. Avoid in pregnancy.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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