Drug interactions
Atomoxetine + Clozapine
Severity: Moderate
Atomoxetine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can prolong the QT interval and cause tachycardia, myocarditis and orthostasis, and atomoxetine increases heart rate and blood pressure. The combination may add to cardiac risk.
What this interaction means in plain words
Atomoxetine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and cardiovascular effects (pharmacodynamic).
What to do
Obtain a baseline ECG and monitor heart rate, blood pressure and electrolytes. Reassess the combination if palpitations, syncope or QT lengthening appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Atomoxetine with Clozapine?
MediHelp rates the interaction as moderate. Atomoxetine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can prolong the QT interval and cause tachycardia, myocarditis and orthostasis, and atomoxetine increases heart rate and blood pressure. The combination may add to cardiac risk.
How serious is the interaction between Atomoxetine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate, blood pressure and electrolytes. Reassess the combination if palpitations, syncope or QT lengthening appear.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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