Drug interactions
Atomoxetine + Efavirenz
Severity: Minor
Atomoxetine and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz has been associated with QT prolongation, and atomoxetine may have a small effect on QT at high exposures. Combined use could add arrhythmia risk in predisposed patients.
What this interaction means in plain words
Atomoxetine and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atomoxetine belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
Possible additive QT interval prolongation.
What to do
Obtain an ECG if the patient has other QT risk factors, and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Efavirenz?
MediHelp rates the interaction as minor. Atomoxetine and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz has been associated with QT prolongation, and atomoxetine may have a small effect on QT at high exposures. Combined use could add arrhythmia risk in predisposed patients.
How serious is the interaction between Atomoxetine and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG if the patient has other QT risk factors, and correct hypokalemia and hypomagnesemia.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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