Drug interactions
Dihydroergotamine + Efavirenz
Severity: Contraindicated
Dihydroergotamine and Efavirenz: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz alters CYP3A4 activity and may change dihydroergotamine exposure unpredictably. Elevated ergot levels risk severe peripheral and cerebral ischemia, so the combination is avoided.
What this interaction means in plain words
Dihydroergotamine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz modulation of CYP3A4 metabolism of dihydroergotamine.
What to do
Avoid and treat migraine with a non-ergot alternative such as a triptan, taking its interactions into account.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
- Efavirenz + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
- Dihydroergotamine + Ergotamine Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Efavirenz?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz alters CYP3A4 activity and may change dihydroergotamine exposure unpredictably. Elevated ergot levels risk severe peripheral and cerebral ischemia, so the combination is avoided.
How serious is the interaction between Dihydroergotamine and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid and treat migraine with a non-ergot alternative such as a triptan, taking its interactions into account.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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