Drug interactions
Atomoxetine + Entrectinib
Severity: Moderate
Atomoxetine and Entrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may add to the risk of torsades de pointes. Atomoxetine has been associated with QT prolongation mainly in overdose or in poor CYP2D6 metabolizers.
What this interaction means in plain words
Atomoxetine and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Entrectinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes (potassium, magnesium) during co-treatment. Correct electrolyte abnormalities and consider an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Atomoxetine with Entrectinib?
MediHelp rates the interaction as moderate. Atomoxetine and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may add to the risk of torsades de pointes. Atomoxetine has been associated with QT prolongation mainly in overdose or in poor CYP2D6 metabolizers.
How serious is the interaction between Atomoxetine and Entrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes (potassium, magnesium) during co-treatment. Correct electrolyte abnormalities and consider an alternative if QTc becomes markedly prolonged.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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