Drug interactions
Amiodarone + Entrectinib
Severity: Major
Amiodarone and Entrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is a moderate CYP3A4 inhibitor and can raise entrectinib exposure, increasing its toxicities. Both drugs also prolong the QT interval, so the risk of torsades de pointes is additive.
What this interaction means in plain words
Amiodarone and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Entrectinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by amiodarone reduces entrectinib clearance, plus additive QT prolongation.
What to do
Prefer an alternative antiarrhythmic. If unavoidable, reduce the entrectinib dose per labeling for moderate CYP3A4 inhibitors and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Entrectinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Amiodarone with Entrectinib?
MediHelp rates the interaction as major. Amiodarone and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone is a moderate CYP3A4 inhibitor and can raise entrectinib exposure, increasing its toxicities. Both drugs also prolong the QT interval, so the risk of torsades de pointes is additive.
How serious is the interaction between Amiodarone and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiarrhythmic. If unavoidable, reduce the entrectinib dose per labeling for moderate CYP3A4 inhibitors and monitor ECG and electrolytes.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
