Drug interactions
Atomoxetine + Givinostat
Severity: Moderate
Atomoxetine and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval and atomoxetine has been associated with QT effects, so the combination may increase arrhythmia risk. Patients with cardiac disease or electrolyte imbalance are more vulnerable.
What this interaction means in plain words
Atomoxetine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Additive QTc prolongation.
What to do
Perform ECGs before starting, during co-administration and when clinically indicated. Withhold the QT-prolonging drug if QTc exceeds 500 ms or rises more than 60 ms from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Atomoxetine with Givinostat?
MediHelp rates the interaction as moderate. Atomoxetine and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval and atomoxetine has been associated with QT effects, so the combination may increase arrhythmia risk. Patients with cardiac disease or electrolyte imbalance are more vulnerable.
How serious is the interaction between Atomoxetine and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECGs before starting, during co-administration and when clinically indicated. Withhold the QT-prolonging drug if QTc exceeds 500 ms or rises more than 60 ms from baseline.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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