Drug interactions
Atomoxetine + Glasdegib
Severity: Moderate
Atomoxetine and Glasdegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and atomoxetine may add to this effect. Together they may raise the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Atomoxetine and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Glasdegib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform a baseline ECG and monitor QTc and electrolytes during co-treatment. Correct hypokalemia and hypomagnesemia, and consider an alternative if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Atomoxetine with Glasdegib?
MediHelp rates the interaction as moderate. Atomoxetine and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and atomoxetine may add to this effect. Together they may raise the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Atomoxetine and Glasdegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and monitor QTc and electrolytes during co-treatment. Correct hypokalemia and hypomagnesemia, and consider an alternative if QTc rises significantly.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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