Drug interactions
Anagrelide + Glasdegib
Severity: Major
Anagrelide and Glasdegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may increase the likelihood of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, heart disease or bradycardia.
What this interaction means in plain words
Anagrelide and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Glasdegib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Avoid the combination where possible. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and repeat ECGs periodically during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
- Azithromycin + Glasdegib Major
Frequently asked questions
Can I take Anagrelide with Glasdegib?
MediHelp rates the interaction as major. Anagrelide and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so using them together may increase the likelihood of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, heart disease or bradycardia.
How serious is the interaction between Anagrelide and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and repeat ECGs periodically during treatment.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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