Drug interactions
Atomoxetine + Pitolisant
Severity: Moderate
Atomoxetine and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval, and its labeling advises caution with other QT-prolonging drugs. Atomoxetine may add to this effect. In addition, pitolisant is a weak CYP2D6 inhibitor and may modestly raise atomoxetine levels.
What this interaction means in plain words
Atomoxetine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus mild CYP2D6 inhibition by pitolisant reducing atomoxetine clearance.
What to do
Monitor ECG in patients with QT risk factors, and watch for increased atomoxetine adverse effects such as tachycardia or hypertension. Reduce the atomoxetine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atomoxetine and Pitolisant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Atomoxetine with Pitolisant?
MediHelp rates the interaction as moderate. Atomoxetine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can prolong the QT interval, and its labeling advises caution with other QT-prolonging drugs. Atomoxetine may add to this effect. In addition, pitolisant is a weak CYP2D6 inhibitor and may modestly raise atomoxetine levels.
How serious is the interaction between Atomoxetine and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with QT risk factors, and watch for increased atomoxetine adverse effects such as tachycardia or hypertension. Reduce the atomoxetine dose if these occur.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
