Drug interactions
Atomoxetine + Quinine
Severity: Moderate
Atomoxetine and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits CYP2D6, the main enzyme that clears atomoxetine, which can raise atomoxetine levels. Both drugs may also prolong QT, increasing the risk of arrhythmia and of increased heart rate and blood pressure.
What this interaction means in plain words
Atomoxetine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
CYP2D6 inhibition by quinine raises atomoxetine exposure, with additive QT effects.
What to do
Monitor ECG, heart rate and blood pressure, and consider a lower atomoxetine dose. Avoid in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Quinine?
MediHelp rates the interaction as moderate. Atomoxetine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits CYP2D6, the main enzyme that clears atomoxetine, which can raise atomoxetine levels. Both drugs may also prolong QT, increasing the risk of arrhythmia and of increased heart rate and blood pressure.
How serious is the interaction between Atomoxetine and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure, and consider a lower atomoxetine dose. Avoid in patients with other QT risk factors.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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