Drug interactions
Atomoxetine + Salmeterol
Severity: Moderate
Atomoxetine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine raises heart rate and blood pressure through noradrenergic effects, and salmeterol can add cardiovascular stimulation such as tachycardia and palpitations. The risk is likely small with inhaled beta-agonists but may matter in patients with cardiovascular disease.
What this interaction means in plain words
Atomoxetine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic sympathomimetic cardiovascular effects.
What to do
Monitor heart rate and blood pressure when starting or adjusting either drug. Reassess in patients reporting palpitations or with known cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Salmeterol?
MediHelp rates the interaction as moderate. Atomoxetine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine raises heart rate and blood pressure through noradrenergic effects, and salmeterol can add cardiovascular stimulation such as tachycardia and palpitations. The risk is likely small with inhaled beta-agonists but may matter in patients with cardiovascular disease.
How serious is the interaction between Atomoxetine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting either drug. Reassess in patients reporting palpitations or with known cardiovascular disease.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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