Drug interactions
Atomoxetine + Selpercatinib
Severity: Moderate
Atomoxetine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and atomoxetine may add to this effect. The combination may increase the risk of ventricular arrhythmia, particularly when electrolytes are abnormal. Both drugs can also raise blood pressure.
What this interaction means in plain words
Atomoxetine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation, with overlapping blood pressure effects.
What to do
Monitor ECG, electrolytes and blood pressure during co-treatment. Correct hypokalemia and hypomagnesemia, and adjust therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Atomoxetine with Selpercatinib?
MediHelp rates the interaction as moderate. Atomoxetine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and atomoxetine may add to this effect. The combination may increase the risk of ventricular arrhythmia, particularly when electrolytes are abnormal. Both drugs can also raise blood pressure.
How serious is the interaction between Atomoxetine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and blood pressure during co-treatment. Correct hypokalemia and hypomagnesemia, and adjust therapy if QTc becomes markedly prolonged.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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