Drug interactions
Amisulpride + Selpercatinib
Severity: Major
Amisulpride and Selpercatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval and amisulpride adds further QT risk. The pair may provoke serious ventricular arrhythmias.
What this interaction means in plain words
Amisulpride and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Avoid if an alternative exists. Otherwise monitor ECG and electrolytes at baseline and periodically, and correct abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Amisulpride with Selpercatinib?
MediHelp rates the interaction as major. Amisulpride and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib can prolong the QT interval and amisulpride adds further QT risk. The pair may provoke serious ventricular arrhythmias.
How serious is the interaction between Amisulpride and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. Otherwise monitor ECG and electrolytes at baseline and periodically, and correct abnormalities.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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