Drug interactions
Atomoxetine + Siponimod
Severity: Moderate
Atomoxetine and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod can slow heart rate and delay atrioventricular conduction, particularly when starting treatment, and atomoxetine has some QT-prolonging potential. The combined effect on rhythm is uncertain but may matter in susceptible patients.
What this interaction means in plain words
Atomoxetine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Why it happens
Possible additive effects on cardiac conduction and repolarization; the mechanism is not firmly established.
What to do
Obtain a baseline ECG before starting siponimod and monitor heart rate during initiation. Use extra care in patients with a prolonged QTc or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Atomoxetine with Siponimod?
MediHelp rates the interaction as moderate. Atomoxetine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod can slow heart rate and delay atrioventricular conduction, particularly when starting treatment, and atomoxetine has some QT-prolonging potential. The combined effect on rhythm is uncertain but may matter in susceptible patients.
How serious is the interaction between Atomoxetine and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting siponimod and monitor heart rate during initiation. Use extra care in patients with a prolonged QTc or other QT-prolonging drugs.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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