Drug interactions
Atomoxetine + Sunitinib
Severity: Moderate
Atomoxetine and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib is associated with QT prolongation and hypertension, and atomoxetine may contribute to both. Together they may increase risk of arrhythmia and elevated blood pressure.
What this interaction means in plain words
Atomoxetine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation and additive pressor effects.
What to do
Obtain ECG and electrolytes at baseline and periodically, and monitor blood pressure. Treat hypertension and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Atomoxetine with Sunitinib?
MediHelp rates the interaction as moderate. Atomoxetine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib is associated with QT prolongation and hypertension, and atomoxetine may contribute to both. Together they may increase risk of arrhythmia and elevated blood pressure.
How serious is the interaction between Atomoxetine and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes at baseline and periodically, and monitor blood pressure. Treat hypertension and avoid further QT-prolonging drugs.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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