Drug interactions
Apalutamide + Sunitinib
Severity: Major
Apalutamide and Sunitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may substantially reduce sunitinib and active metabolite exposure, compromising efficacy. Sunitinib labeling advises avoiding strong CYP3A4 inducers.
What this interaction means in plain words
Apalutamide and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Sunitinib belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, increasing sunitinib clearance.
What to do
Avoid concomitant use. If unavoidable, increase the sunitinib dose per labeling with careful toxicity monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Sunitinib
Frequently asked questions
Can I take Apalutamide with Sunitinib?
MediHelp rates the interaction as major. Apalutamide and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may substantially reduce sunitinib and active metabolite exposure, compromising efficacy. Sunitinib labeling advises avoiding strong CYP3A4 inducers.
How serious is the interaction between Apalutamide and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. If unavoidable, increase the sunitinib dose per labeling with careful toxicity monitoring.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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