Drug interactions
Atorvastatin + Butabarbital
Severity: Moderate
Atorvastatin and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate that can induce hepatic and intestinal CYP3A4. Atorvastatin exposure may fall, which can weaken its LDL-lowering effect.
What this interaction means in plain words
Atorvastatin and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases the metabolism of atorvastatin.
What to do
Check the lipid profile after starting or stopping butabarbital and increase the atorvastatin dose if the response is inadequate. Consider a statin less dependent on CYP3A4 if control remains poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Butabarbital?
MediHelp rates the interaction as moderate. Atorvastatin and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate that can induce hepatic and intestinal CYP3A4. Atorvastatin exposure may fall, which can weaken its LDL-lowering effect.
How serious is the interaction between Atorvastatin and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the lipid profile after starting or stopping butabarbital and increase the atorvastatin dose if the response is inadequate. Consider a statin less dependent on CYP3A4 if control remains poor.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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