Drug interactions
Atorvastatin + Butalbital
Severity: Minor
Atorvastatin and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with CYP3A4 inducing potential. Concurrent use may lower atorvastatin concentrations and reduce lipid-lowering efficacy, although intermittent butalbital use makes the effect less predictable.
What this interaction means in plain words
Atorvastatin and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-related induction of CYP3A4 may increase atorvastatin metabolism.
What to do
No routine dose change is needed; recheck lipids if butalbital is taken regularly over a prolonged period and adjust the atorvastatin dose if LDL targets are not met.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Butalbital?
MediHelp rates the interaction as minor. Atorvastatin and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with CYP3A4 inducing potential. Concurrent use may lower atorvastatin concentrations and reduce lipid-lowering efficacy, although intermittent butalbital use makes the effect less predictable.
How serious is the interaction between Atorvastatin and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; recheck lipids if butalbital is taken regularly over a prolonged period and adjust the atorvastatin dose if LDL targets are not met.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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